The Michigan Brain Bank inventory has a diverse disease compilation (see inventory below). Each donated brain is bisected through the midline into two hemispheres. One hemisphere is submitted for fixation in 10% neutral buffered formalin, dissected, processed into paraffin and assessed microscopically by experienced University of Michigan Neuropathologists, providing diagnostic confirmation. The other hemisphere is dissected into coronal sections and frozen using either liquid nitrogen vapor or cold contact. The tissues are suitable for a wide variety of applications, including polymerase chain reaction (PCR), DNA sequencing, mRNA isolation, receptor binding, immunohistochemistry, in situ hybridization, virus detection, and certain chemical assays.
If you are interested in obtaining frozen or paraffin tissue please complete the resource application below and email it to UMHSbrainbank@med.umich.edu. University of Michigan investigators can expect their requests to be completed within a week. External investigators may be asked to pay for the cost of tissue transportation and these requests may take longer to complete depending on circumstances. If you have any questions please contact the Brain Bank Coordinator at (734) 647-7648.
Brain Bank Inventory